Immune responses in type 1 diabetes
Research type
Research Study
Full title
Immunological mechanisms underlying the genetic basis for natural protection from T1D
IRAS ID
338213
Contact name
Margarita Dominguez-Villar
Contact email
Sponsor organisation
Imperial College London
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
5 years, 11 months, 31 days
Research summary
Type 1 diabetes (T1D) is a chronic autoimmune disease in which immune cells attack and destroy beta cells in the pancreas, which are in charge of producing insulin. Therefore, people with T1D are not able to control their glucose levels adequately. A number of works have identified variations in the sequence of certain parts of the genome (close to or in genes) that are associated with protection from T1D or increased risk to develop T1D. The aim of this project is to study the immune cells in people with T1D and unaffected individuals (siblings or unrelated subjects) that harbor either protective, risk, or both protective and risk variations in their genome. We will examine how functional those cells are, and whether there are differences in their phenotype in individuals that harbor protective gene variations as compared to those that harbor genome variations that confer increased risk to T1D development.
REC name
West of Scotland REC 5
REC reference
24/WS/0096
Date of REC Opinion
25 Jul 2024
REC opinion
Further Information Favourable Opinion