Immune and Inflammatory Signalling in Patients with Renal Disease
Research type
Research Study
Full title
Immune and Inflammatory Signalling in Patients with Renal Disease
IRAS ID
289590
Contact name
Stephen McAdoo
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Chronic kidney disease (CKD) is common, with an estimated global prevalence of 15%. Progression to end-stage kidney disease (ESKD), requiring long term treatment renal replacement therapy (RRT) with dialysis or kidney transplantation, represents a significant economic healthcare burden. Despite access to RRT, CKD and ESKD are associated with significant morbidity and mortality, particularly related to cardiovascular disease, the leading cause of death in patients with kidney disease.
Many common causes of CKD and ESKD share immune-mediated mechanisms of kidney injury. The immune system consists of white blood cells which normally help people to fight infections. However, in some people, the immune system dysfunctions and begins to attack the kidney.
This project aims to better understand the mechanism of immune dysfunction in a range of kidney ESKD and its complications, and potential therapeutic targets. We have a large cohort of renal patients with a broad range of renal disease which will allow us to complete this analysis.
REC name
West of Scotland REC 5
REC reference
20/WS/0181
Date of REC Opinion
15 Dec 2020
REC opinion
Favourable Opinion