IMAGING ANGIOGENESIS IN PATIENTS WITH AVMs AND HHT USING PET CT
Research type
Research Study
Full title
IMAGING ANGIOGENESIS BY PET CT – A PILOT STUDY IN PATIENTS WITH ARTERIOVENOUS MALFORMATIONS AND HEREDITARY HAEMORRHAGIC TELANGIECTASIA
IRAS ID
253085
Contact name
Claire Shovlin
Contact email
Sponsor organisation
Imperial College London and Imperial College Healthcare NHS Trust
Duration of Study in the UK
2 years, 8 months, 4 days
Research summary
Pulmonary arteriovenous malformations (AVMs)are abnormal blood vessels in the lungs that affect >10,000 people in the UK, and cause preventable haemorrhage, strokes and death. [1] Pulmonary AVM screening and treatments are recommended nationally and internationally.[1-3]. However, these investigations and interventions can carry risks. A major concern is that if current international guidance for follow up were introduced in the UK, many patients would receive very high cumulative radiation exposure.[4] Identification of unstable AVMs offers opportunities to target screening and therapy to patients at highest risk of pulmonary AVM complications. The goal of this study is to better establish the new growth (angiogenesis) characteristics of AVMs, in order to optimize long term follow up of patients. We will do this using PET CT scans of patients (Cohort 1) and immunohistochemistry of resected AVMs (Cohort 2) using a new 68Ga-RGD tracer for the angiogenesis target αvß3 integrin.
[1] Pulmonary arteriovenous malformations emerge from the shadows. Thorax. 2017 Dec;72(12):1071-1073.
[2] International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia. J Med Genet. 2011 Feb;48(2):73-87.
[3] British Thoracic Society Clinical Statement on Pulmonary Arteriovenous Malformations. Thorax. 2017 Dec;72(12):1154-1163
[4] Cumulative radiation dose in patients with hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations. Can Assoc Radiol J. 2014 May;65(2):135-40REC name
West of Scotland REC 3
REC reference
19/WS/0129
Date of REC Opinion
12 Dec 2019
REC opinion
Further Information Favourable Opinion