IMAGING ANGIOGENESIS IN PATIENTS WITH AVMs AND HHT USING PET CT

  • Research type

    Research Study

  • Full title

    IMAGING ANGIOGENESIS BY PET CT – A PILOT STUDY IN PATIENTS WITH ARTERIOVENOUS MALFORMATIONS AND HEREDITARY HAEMORRHAGIC TELANGIECTASIA

  • IRAS ID

    253085

  • Contact name

    Claire Shovlin

  • Contact email

    c.shovlin@imperial.ac.uk

  • Sponsor organisation

    Imperial College London and Imperial College Healthcare NHS Trust

  • Duration of Study in the UK

    2 years, 8 months, 4 days

  • Research summary

    Pulmonary arteriovenous malformations (AVMs)are abnormal blood vessels in the lungs that affect >10,000 people in the UK, and cause preventable haemorrhage, strokes and death. [1] Pulmonary AVM screening and treatments are recommended nationally and internationally.[1-3]. However, these investigations and interventions can carry risks. A major concern is that if current international guidance for follow up were introduced in the UK, many patients would receive very high cumulative radiation exposure.[4] Identification of unstable AVMs offers opportunities to target screening and therapy to patients at highest risk of pulmonary AVM complications. The goal of this study is to better establish the new growth (angiogenesis) characteristics of AVMs, in order to optimize long term follow up of patients. We will do this using PET CT scans of patients (Cohort 1) and immunohistochemistry of resected AVMs (Cohort 2) using a new 68Ga-RGD tracer for the angiogenesis target αvß3 integrin.
    [1] Pulmonary arteriovenous malformations emerge from the shadows. Thorax. 2017 Dec;72(12):1071-1073.
    [2] International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia. J Med Genet. 2011 Feb;48(2):73-87.
    [3] British Thoracic Society Clinical Statement on Pulmonary Arteriovenous Malformations. Thorax. 2017 Dec;72(12):1154-1163
    [4] Cumulative radiation dose in patients with hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations. Can Assoc Radiol J. 2014 May;65(2):135-40

  • REC name

    West of Scotland REC 3

  • REC reference

    19/WS/0129

  • Date of REC Opinion

    12 Dec 2019

  • REC opinion

    Further Information Favourable Opinion