Imaging and EEG Predictors of Post-Stroke Epilepsy
Research type
Research Study
Full title
Human epileptogenesis in the post-stroke brain: Mapping affected networks using advanced structural and functional imaging techniques.
IRAS ID
138527
Contact name
Beate Diehl
Contact email
Sponsor organisation
UCLH/UCL/Royal Free Joint Research Office, UCL
Research summary
Stroke is the most common cause of epilepsy in people over the age of 60. Every year, around 150,000 people in the UK have a stroke, causing injury either by cutting off the blood supply or by bleeding into the brain. During the acute phase of the stroke, irritation at the site of injury can cause a seizure. Seizures can also occur much later, and then carry a significant risk for a patient to develop epilepsy. It is not known why some patients develop epilepsy and others do not.
We wish to determine who is at risk for post-stroke epilepsy, using advanced MR imaging and EEG measures. This could help to identify those who may benefit from early intervention to prevent development of epilepsy.
To understand how brains of patients with and without post stroke epilepsy differ, selected patients with and without epilepsy will be offered participation in a small study. We will image the connections and networks in the brain using structural MRI, as well as functional MRI and simultaneous EEG recordings.
This study is conceptualised as a feasability study, however, it is ultimately planned to expand the study group and further funding is currently sought for this.REC name
London - Queen Square Research Ethics Committee
REC reference
13/LO/1809
Date of REC Opinion
13 Jan 2014
REC opinion
Further Information Favourable Opinion