Imaging Amyloidosis with PET/MRI

• Research type

  Research Study

• Full title

  Imaging Cardiac and Systemic Amyloidosis using 18F-Florbetapir Positron Emission Tomography (PET), relationship with Magnetic Resonance imaging (MRI) using simultaneous hybrid PET/MRI; a pilot study.

• IRAS ID

  129973

• Contact name

  Leon Menezes

• Contact email

  leon.menezes@uclh.nhs.uk

• Sponsor organisation

  University College London

• Research summary

  Systemic amyloidosis is a relatively rare multi-system disease caused by the deposition of mis-folded protein in various tissues and organs. Cardiac involvement is a leading cause of morbidity and mortality, especially in primary light chain (AL) amyloidosis and in transthyretin (TTR) amyloidosis. Current methods of assessment do not directly quantify myocardial amyloid burden. There are a characteristic features on cardiac magnetic resonance imaging (MRI). The Positron Emission Tomography (PET) radio-tracer 18F Florbetapir was developed for the visualisation and quantification of amyloid plaques in Alzheimer's disease. The radiotracer may allow direct visualisation of systemic and cardiac amyloid deposition. This study proposes to attempt to directly image amyloid deposition in systemic amyloid, using hybrid PET/MRI, with the future potential to diagnose and monitor treatment response in this condition.

• REC name

  London - Bromley Research Ethics Committee

• REC reference

  14/LO/0028

• Date of REC Opinion

  18 Jun 2014

• REC opinion

  Further Information Favourable Opinion