IMAGINE
Research type
Research Study
Full title
Intellectual Disability and Mental Health: Assessing Genomic Impact on Neurodevelopment.
IRAS ID
153245
Contact name
Frances Lucy Raymond
Contact email
Sponsor organisation
Cambridge University HospitalNHS Foundation Trust and University of Cambridge
Research summary
The IMAGINE programme of research aims to identify genomic, environmental and developmental factors that are predictive of mental health outcomes within the intellectually disabled (ID) population. This pilot programme will involve the pragmatic but systematic NHS-based ascertainment and online parent-reported phenotyping of a national representative sample of individuals with genomic abnormalities associated with ID (~10-15% of the ID population overall), and deep phenotyping of selected subsets of individuals with high-risk CNVs based on existing literature and online results. The IMAGINE cohort and datasets will generate extensive opportunities for future collaborative translational research. In this pilot proposal we intend to establish the feasibility of the IMAGINE programme within a 12 month framework of research, commencing June 2014. We aim to submit the results of the pilot study, together with an amended Case for Support, for consideration at the July 2015 MRC Neurosciences and Mental Health Board to extend the funding for 5 further years to collect data on 10,000 indiiduals and families.
Pilot study: Aims and Objectives
The pilot study aims to establish the administrative, technological and validation of the methodological framework required to deliver the IMAGINE programme of research. All major aspects of the original full application will be critically evaluated. The main objectives of the pilot project include the opportunity to amend the original proposal where necessary, in order to facilitate rapid and effective escalation to the full IMAGINE programme, if funded. Accordingly, there will be added value to the substantive IMAGINE programme, as the pilot will establish a feasible infrastructure for that programme.REC name
London - Queen Square Research Ethics Committee
REC reference
14/LO/1069
Date of REC Opinion
14 Aug 2014
REC opinion
Further Information Favourable Opinion