IgE Biomarkers
Research type
Research Study
Full title
Biomarkers of IgE-producing cells and their pre-cursors
IRAS ID
317307
Contact name
Louisa James
Contact email
Sponsor organisation
Queen Mary University of London
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
We are trying to find out why people get ‘IgE-mediated disease’ (such as asthma and allergies) and develop better ways to help them. Antibodies are specialised proteins produced by a type of white blood cell, called a B cell. They are used by our immune system to fight infections. Our B cells can produce five different types of antibodies. For our immune system to correctly work our B cells must produce the correct type of antibodies. People develop an allergy or have asthma because their B cells produce too much of one type of antibody, called IgE. This work will investigate the properties of B cells that make this specific antibody type, to find the best way to stop this happening. We will collect blood and nasal tissue samples from people who are undergoing nasal surgery as part of their routine clinical care. We will isolate B cells from these samples and analyse the genes that are being expressed by the cells in relation to the type of antibody those cells are making.
REC name
West of Scotland REC 3
REC reference
22/WS/0156
Date of REC Opinion
30 Nov 2022
REC opinion
Further Information Favourable Opinion