Identifying risk factors for developing AKI in sepsis
Research type
Research Study
Full title
A retrospective study to evaluate the prevalence of acute kidney injury in patients with DKA and sepsis
IRAS ID
293819
Contact name
Siva Oruganti
Contact email
Sponsor organisation
Cardiff and Vale University Health Board
Duration of Study in the UK
1 years, 0 months, 28 days
Research summary
We aim to evaluate the prevalence of acute kidney injury (AKI) or kidney failure in children admitted to Paediatric Intensive Care Unit (PICU) with sepsis, also called blood poisoning. We plan to compare this with the prevalence of AKI in children admitted with a complication of Diabetes called Diabetes Keto Acidosis (DKA). Even though sepsis and DKA two different conditions, both medical problems are associated with evidence of reduced blood supply and hence are treated with fluid replacement.
There has been growing evidence that the risk of AKI in sepsis can be improved with using Intravenous fluids with lower Chloride levels than previously used.
Acute Kidney Injury (AKI) is a clinical condition where the kidney's function declines and can lead to kidney failure. Patients admitted to paediatric intensive care with sepsis or blood poisoning are at risk of developing AKI. We are interested in identifying factors that are associated with AKI. This may help in improving our understanding the risks of AKI and ways of preventing in the future.
Sepsis or septic shock has a prevalence of 7% -9% in children admitted to paediatric intensive care units and nearly 20% have evidence of reduced or loss of kidney function associated with severe sepsis.
As there may be other factors which contribute to the higher incidence of renal failure in children with sepsis, it is important we identify those factors.
With the assumption that the incidence of Acute Kidney Injury is higher in children with sepsis when compared to children with DKA, we hypothesise that there are multiple factors associated with Acute Kidney Injury in children with sepsis and the prevalence of hyperchloremia in both groups is similar.REC name
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REC reference
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