IDEE
Research type
Research Study
Full title
Improving the diabetic heart’s energy efficiency (IDEE)
IRAS ID
308132
Contact name
Eylem Levelt
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
3 years, 0 months, 4 days
Research summary
About one in seventeen people in the UK has type 2 diabetes. Heart failure is one of the most common complications of this disease. Once the heart failure is established, only one in five patients survive beyond five years despite modern treatment options for improving heart function. This high risk of death is alarming and highlights the importance of preventing the development of heart failure in patients with type 2 diabetes.
The association between heart failure and mitochondrial dysfunction is well established, however there are very limited therapies targeting this specific pathway. Mitochondrial dysfunction is linked to increased oxidative stress, and this link has led to research to investigate the role of antioxidants to treat cardiac disease (including heart failure). Mitoquinone is an over the counter supplement which works as an antioxidant.
In the research we are now proposing, patients will be given Mitoquinone for 16 weeks or they will be randomised to receive no Mitoquinone. Using scanners, we will assess the heart’s energy status, pumping function, and blood supply before and after Mitoquinone supplement. This work will help us understand much better how Mitoquinone works and if it can improve myocardial energetics in patients with diabetes.
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
23/EM/0074
Date of REC Opinion
21 Mar 2023
REC opinion
Favourable Opinion