Ideal and prolonged length of stay after ovarian cancer cytoreduction
Research type
Research Study
Full title
A retrospective observational study of ideal and prolonged length of stay following ovarian cancer cytoreduction with an insight into the current COVID-19 pandemic era
IRAS ID
282396
Contact name
Alexandros Laios
Contact email
Sponsor organisation
Leeds Teaching Hospitals NHS Trust
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
0 years, 3 months, 0 days
Research summary
Whilst treatment for advanced ovarian cancer (AOC) is aimed to delay progression and prolong remission, many patients will achieve long and durable remissions. Cytoreductive surgery to achieve complete removal of all visible cancer often requires prolonged surgical time and possible multi-visceral resection potentially necessitating ICU support and prolonged hospitalisation. Length of stay (LOS) has been suggested as a marker of the quality of short-term care or effectiveness of care. Different MDTs treat populations with different characteristics, which makes LOS prediction challenging. There is a growing interest in monitoring hospital stays and compare performance to improve standards of care. We will refine factors that significantly affect both ideal and prolonged LOS in AOC patients undergoing cytoreductive surgery and create risk-adjusted prediction models based on MDT workload. AOC patients who had their diagnosis and surgical treatment from Jan 2014 will be identified from the PPM+ and assessed for eligibility. Logistic regression will be employed to predict ideal and prolonged LOS based on selected clinical variables. We will measure “expected” ideal and prolonged LOS rates for our MDT from individual’s probability of staying in the hospital in the defined periods. We will be able to refine risk-adjusted predictors of ideal LOS and demonstrate reduction in LOS over the study period following adoption of ERAS pathways and identify stubborn populations, wherein prolonged LOS despite interventions remains substantial. We will be particularly interested in recording LOS during the COVID-19 era following implementation of new strategies to optimise care for patients while at the same time offering options to alleviate the burden to the healthcare system when resources may need to be diverted to the direct care of patients.
REC name
London - City & East Research Ethics Committee
REC reference
20/PR/0058
Date of REC Opinion
18 Jun 2020
REC opinion
Favourable Opinion