IDEAL
Research type
Research Study
Full title
Investigating immune dysfunction in infection, inflammation and liver disease.
IRAS ID
341853
Contact name
Lucia Possamai
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
3 years, 4 months, 31 days
Research summary
The IDEAL study is a basic science cohort observational study aiming to investigate differences in the number, make up and function of immune cells (white blood cells) in patients in different stages of health.
The immune system is composed of a number of different cells, which are normally tasked with fighting infection. It is known that in patients with severe infection, inflammation and/or liver disease, the capability of the immune system to fight infection can be disturbed.
We are interested in investigating differences in immune cells we observe when comparing patients with liver disease, those with a suspected or confirmed infection, those who are at an increased risk of developing infection or those who are healthy.
By identifying any differences in these cells, we hope to improve our understanding of why certain patients are more susceptible to infection and ill-health as a result, as well as identify potential ways to help remedy defects in the immune system. By doing so, we may be able to find new targets for future treatments that can help reduce susceptibility to and worse outcomes related to infection.
REC name
London - Queen Square Research Ethics Committee
REC reference
24/LO/0696
Date of REC Opinion
25 Oct 2024
REC opinion
Further Information Favourable Opinion