ICP vs body fat
Research type
Research Study
Full title
Correlation between intracranial pressure as measured by lumbar puncture manometry and percentage body fat as measured by air-displacement plethysmography
IRAS ID
164528
Contact name
Benjamin R Wakerley
Contact email
Sponsor organisation
Gloucestershire Royal Hospitals NHS foundation Trust
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Background: It has already been established that there is a weak positive relationship between increased intracranial pressure (ICP), as measured by lumbar puncture manometry, and increased Body Mass Index (BMI). This is also observed clinically in some patients with idiopathic intracranial hypertension, who typically have raised BMI. The relationship between BMI and percentage body fat is non-linear, especially at BMI > 40. The Bod Pod device enables non-invasive body composition profiling, including accurate calculation of percentage body fat, without the use of radiation.
Aim: To examine the relationship between intracranial pressure as measured by lumbar puncture manometry and percentage body fat as measured by air-displacement plethysmography (Bod Pod)
Methods: 100 patients undergoing routine diagnostic and therapeutic lumbar punctures for a variety of non-emergency neurological conditions will be recruited. Cerebrospinal fluid opening pressure will be measured using standard manometry techniques. Blood pressure, height, weight, collar size, waist size and hip size will be measured. Body composition profiling will be carried out using the Bod Pod.
REC name
London - Bromley Research Ethics Committee
REC reference
14/LO/2266
Date of REC Opinion
17 Dec 2014
REC opinion
Further Information Favourable Opinion