ICH: Measurement of intraventricular haemorrhage & prognostic scores

• Research type

  Research Study

• Full title

  Predicting survival and hydrocephalus an existing dataset of patients with spontaneous intracerebral haemorrhage

• IRAS ID

  140651

• Contact name

  Adrian Parry-Jones

• Contact email

  adrian.parry-jones@manchester.ac.uk

• Sponsor organisation

  University of Manchester

• Research summary

  Based on current figures, bleeding within the brain (intracerebral haemorrhage; ICH) is expected to affect 600,700 people each year in Greater Manchester. Nearly half of these patients may die within one month and those surviving are often left dependent on others. Despite improvements in clinical care and in reducing risk factors, the numbers of cases and subsequent death rate has not significantly changed in the last 3 decades.

  In our previous study (11/H1011/3) we established a dataset of (1175) patients presenting to Greater Manchester Neuroscience Centre (GMNC) with acute ICH over a 3 year period and this information was used in the development of Trust policies for the management of blood pressure and correction of anticoagulation after ICH.

  We now seek permission to perform secondary analysis of the imaging data within the dataset. Following ICH there is considerable swelling of brain tissue; known as hydrocephalus. The amount of hydrocephalus along with blood from the haemorrhage leads to restricted space in the skull and ultimately, pressure on the brain tissue. We wish to measure the amount and location of hydrocephalus and also test the utility of a new predictive ‘score’. The score is based on the measurement of bleeding into the ventricles (fluid filled spaces) within the brain after ICH. This is known as the Graeb score. We will measure the Graeb score from anonymised computed tomography (CT) imaging collected a part of the first study. By using this score along with existing data we will test a new prognostic tool; Tomographic Intracerebral Hemorrhage Score (TIHS) devised by a member of our collaborating team (Di Napoli) to predict survival after ICH. It is hoped this may further inform the development of a care pathway for the investigation and management of patients with ICH.

• REC name

  West Midlands - Coventry & Warwickshire Research Ethics Committee

• REC reference

  14/WM/0086

• Date of REC Opinion

  27 Feb 2014

• REC opinion

  Favourable Opinion