’Iatrogenic’ chronotropic incompetence in heart failure

• Research type

  Research Study

• Full title

  Iatrogenic chronotropic incompetence and exercise tolerance in heart failure

• IRAS ID

  129113

• Contact name

  Klaus Witte

• Contact email

  k.k.witte@leeds.ac.uk

• Sponsor organisation

  University of Leeds

• Research summary

  Patients with CHF benefit from heart rate lowering, and we have previously demonstrated that this does not adversely affect exercise tolerance. In a pacemaker population we also have shown that preventing heart rate lowering is detrimental in terms of symptoms and prognosis. The aim of the present study is therefore to establish whether heart rate limitation in patients with heart failure has a negative impact on exercise capacity. If we establish that this is not the case, physicians will be able to confidently prescribe heart rate lowering agents, and programme pacemakers to allow bradycardia without the concern that there will be detrimental effects on symptoms.

• REC name

  Yorkshire & The Humber - South Yorkshire Research Ethics Committee

• REC reference

  13/YH/0144

• Date of REC Opinion

  12 Jun 2013

• REC opinion

  Further Information Favourable Opinion