Hyperspectral Endoscopy for Early Barrett’s-related Cancer Detection
Research type
Research Study
Full title
Prospective pilot cohort study to assess early diagnostic utility of Hyperspectral Endoscopy for detection of early neoplasia in Barrett's oesophagus
IRAS ID
334612
Contact name
Massimiliano di Pietro
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
A096838, R&D
Duration of Study in the UK
1 years, 11 months, 31 days
Research summary
Cancer of the food pipe (oesophagus) is often detected late, making it hard to treat. To find cancer early, or even spot changes before cancer develops, doctors routinely check people who have a higher risk of developing such cancer. They do this by inserting a flexible tube into their food pipe through the mouth. The tube uses light to illuminate the food pipe and includes a very small camera at the tip that takes a movie inside the body. The tube is called an endoscope, but it just replicates what our eyes could see if we were looking inside the body, which is a challenge because early cancer looks very similar to our eyes as normal healthy tissue.
We have developed a new system that uses a standard endoscope but where the white light is replaced by light of many colours, from blue to red and beyond. We expect, based on early results from previous studies, that using many colours could make it easier to see cancer while it is still in the early stages. The goal of this study is to test if we are able to better detect cancer by comparing standard endoscopy using white light to our new endoscopy system using multi-coloured light.
REC name
Wales REC 6
REC reference
24/WA/0091
Date of REC Opinion
27 Mar 2024
REC opinion
Favourable Opinion