Hyperoxaemia
Research type
Research Study
Full title
Myocardial Perfusion and Microvascular Dysfunction in Stable Coronary Artery Disease During Hyperoxaemia
IRAS ID
157812
Contact name
John P Greenwood
Contact email
Sponsor organisation
University of Leeds
Research summary
Coronary artery disease (CAD) is a leading cause of death and disability worldwide. Around 20-40% of the UK population will experience chest pain during their lifetime, accounting for 40% of acute hospital admissions. Oxygen has long been advocated as a therapeutic agent and treatment option in the management of chest pain, although the scientific basis for this is questionable and there is currently no clinical evidence to support the routine use of oxygen in the setting of myocardial ischaemia. Experimental data suggests hyperoxaemia may actually be harmful purported to be due to alteration in microvascular function. This study is divided into two parts: A. we intend to quantify myocardial blood flow with cardiovascular magnetic resonance (CMR) scanning. B. we intend to use novel invasive coronary physiological measurements to assess the dynamic response of the coronary microvasculature to the hyperoxaemic stimulation. This study will establish the implications of high flow oxygen on coronary microvascular function and may have a direct impact on clinical care and the management of patients presenting with chest pain.
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
14/YH/1089
Date of REC Opinion
4 Sep 2014
REC opinion
Further Information Favourable Opinion