Hydralazine/Nitrates in Heart Failure
Research type
Research Study
Full title
Assessing the Acute Haemodynamic Effects of Hydralazine and Nitrates, singly and in combination, in Patients with Chronic Heart Failure using Novel Non-invasive Sensor Technologies.
IRAS ID
123158
Contact name
John Cleland
Contact email
Sponsor organisation
Hull and East Yorkshire Hospitals NHS Trust
Research summary
We intend to investigate how good new non-invasive sensors are in detecting the response of the heart and circulation to single doses of two types of medicines that have been in widespread use (nitrates and hydralazine), alone and in combination, for the management of heart failure. The additional effects of a range of physiological manoeuvres (such as standing and leg raising) on haemodynamics will also be studied. The focus of this study is to assess the ability of a battery of non-invasive sensors to detect and track changes in congestion and haemodynamics.
This is an observational study that will involve twenty six patients (16 stable, chronic heart failure and 10 controls). The heart failure patients will be studied on four occasions while the control subjects will have one study visit.
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
13/YH/0059
Date of REC Opinion
12 Mar 2013
REC opinion
Favourable Opinion