How many stem cells do I get from liposuction around hip and abdomen?
Research type
Research Study
Full title
Evaluation of the quality and quantity of cells isolated from lipoaspirate stromal vascular fraction using different methods and from different sites.
IRAS ID
247433
Contact name
Richard Field
Contact email
Sponsor organisation
Epsom and St.Helier Hospital University Hospital NHS Trust
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
It is believed that injecting stem cells into osteoarthritic joints may be beneficial for the treatment of osteoarthritis. Stem cells are found in many parts of the body including bone marrow and fat. Some doctors are using purified cells from fat as a treatment for osteorthritis. However, it is not known whether the abdomen (tummy) or hip (buttock) fat provides the best source of stem cells. Neither is it clear how best to extract the stem cells from the fat cells without damaging them.
We therefore, wish to undertake a study to investigate the number and quality of stem cells found in fat extracted from the abdomen or buttocks. We want to ascertain which is the most valuable site - and whether this is conclusive or whether it is different in all participants.
Low volumes of body fat (much less than that taken in normal liposuction) will be aspirated from both the abdomen and buttock, with or without local anaesthetic (but under general anaesthethic), of willing participants whilst they are undergoing a hip replacement.
The fat will be transported to the laboratory where stem cells will be extracted from the fat sample. The cells will be counted and analysed; samples will be kept for 2 years before being destroyed.
The reason to do this project is to understand the best way to obtain cells from body fat tissue so that we can develop this approach as a possible treatment option for patients with osteoarthritis.
REC name
London - Riverside Research Ethics Committee
REC reference
19/LO/0856
Date of REC Opinion
21 Nov 2019
REC opinion
Further Information Favourable Opinion