Hormone receptors in idiopathic subglottic stenosis
Research type
Research Study
Full title
Hormone receptors in idiopathic subglottic stenosis
IRAS ID
311388
Contact name
Chaitanya Gadepalli
Contact email
Sponsor organisation
Northern Care Alliance NHS Foundation trust
Duration of Study in the UK
0 years, 8 months, 1 days
Research summary
Idiopathic Subglottic stenosis (ISGS) is narrowing of the area immediately below the level of vocal cords and upper trachea of unknown aetiology. This airway stenosis causes significant morbidity and if left un treated can cause mortality. This disease is very rare and exclusively seen in women with a median age of presentation around 50 years. The disease is more common in women of Caucasian origin. Due to rarity of the disease, there is poor awareness and understanding. It is diagnosed by clinical history, radiological investigations, autoimmune screen and direct examination by means of endoscopy under anaesthetic. Biopsy of the subglottis is taken to exclude any other rare conditions such as vasculitis. The treatment of this condition is surgical methods only such as dilatation of the airway, division of adhesions or resection of the stenosed segment and surgical re-construction of the airway. The unique existence of this disease in women has led to the hypothesis of imbalance of female hormones such as oestrogens and progesterone in the subglottis by various researchers in various parts of the world. Knowing the imbalance of the receptors and pattern of scar will help us to understand the disease better thereby helping in management of this complex rare disease. As a part of workup of the patients with ISGS, biopsy is taken from the subglottis. With permission of patients, the tissue taken for biopsy can be tested for expression of various hormone receptors.
REC name
London - West London & GTAC Research Ethics Committee
REC reference
23/PR/0436
Date of REC Opinion
11 May 2023
REC opinion
Further Information Favourable Opinion