HOPE atlas
Research type
Research Study
Full title
Visualising cardiovascular pathology using Computed Tomography: The Heart multi-Omics imaging Atlas ProjEct (HOPE Atlas)
IRAS ID
278912
Contact name
Charalambos Antoniades
Contact email
Sponsor organisation
University of Oxford / Clinical Trials and Research Governance
Duration of Study in the UK
2 years, 0 months, 6 days
Research summary
Perivascular adipose tissue (PVAT) adjacent to coronary arteries is recognized as a important regulator of coronary artery disease (CAD). The Fat Attenuation Index (FAI) on CT captures the changes in composition of PVAT and it is associated with cardiovascular risk and mortality. Coronary artery radiomic analysis is the next step to extract more valuable information encoded within the PVAT with direct link to biological mechanisms that reflect early changes in CAD. We aim to achieve this through the study of post-mortem CT angiogram (PMCTA) to allow radiomic analysis of the adipose tissue surrounding the coronary arteries, chambers of the heart, main blood blood vessels in the neck supplying the brain, and retrieve tissue samples from the same sites for analysis of disease processes occurring at these sites. The hypothesis is that there would be CT radiomic biomarkers for different stages of CAD, inflammation surrounding the heart, and blood vessels in the neck and they could be used clinically to stratify and predict disease severity of CAD and stroke risk prediction. The aims of this study are the development of radiomic signatures that describe specific biological processes relevant to CAD and stroke risk which are validated by laboratory experiments with tissue samples from the coronary arteries, heart chambers and blood vessels in the neck supplying the brain. This also creates linked data libraries between radiomic data and laboratory data to enable future validation of novel radiomic biomarkers developed in external cohorts of living patients.
REC name
South Central - Oxford B Research Ethics Committee
REC reference
20/SC/0394
Date of REC Opinion
11 Jan 2021
REC opinion
Further Information Favourable Opinion