Home-based resistance exercise training in CKD
Research type
Research Study
Full title
Home-based progressive resistance exercise training in patients with non-dialysis chronic kidney disease: a randomised delayed-start trial (REPS-KD)
IRAS ID
273437
Contact name
Alice Smith
Contact email
Sponsor organisation
University of Leicester
ISRCTN Number
ISRCTN53557203
Duration of Study in the UK
2 years, 8 months, 30 days
Research summary
Patients with chronic kidney disease (CKD) have low skeletal muscle mass and poor muscle function. This is a result of numerous factors, including inflammation, poor diet, and lack of physical exercise. The loss of both muscle mass and function reduces a patient’s ability to perform everyday tasks and decreases quality of life. This loss of muscle mass, strength, and physical function is termed ‘sarcopenia’ and is a recognised muscle disease. In patients with CKD interventions to maintain muscle mass and function are important. Exercise may provide a simple and affordable means to help reduce muscle impairment in CKD, and in particular, resistance exercise training is fundamental for muscle health. The benefits of supervised resistance exercise in a gym-based setting is well known, however it is unlikely that this type of intervention is suitable for everyone and better home-based programmes for CKD patients are needed.
This proposed study is divided into four parts (A, B, C, and D). Part A is a simple questionnaire-based study that will explore the number of patients with sarcopenia in CKD. In Part B we will invite a small number of patients to come in and undergo informal interviews to explore attitudes towards sarcopenia and the role of home-based resistance exercise training in CKD. The information we collect will then be used in Part C where we will develop a home-based progressive resistance exercise training intervention for patients. In this part, we will also get a few patients to test parts of the programme and give us feedback on what they thought. In Part D, we will then test whether an 8 week home-based resistance exercise training intervention can be performed in patients with CKD.
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
20/EM/0029
Date of REC Opinion
17 Apr 2020
REC opinion
Further Information Favourable Opinion