HLA Prevalence
Research type
Research Study
Full title
HLA Prevalence: The Prevalence of different HLA types in people living with HIV and/or Hepatitis B
IRAS ID
315434
Contact name
Julie Fox
Contact email
Sponsor organisation
Guy's & St. Thomas' NHS Foundation Trust
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
HLA typing is a test that looks closely at certain parts of the immune system. It is used to find out if someone would be a good donor match for a person who needs a transplant. More recently, it has been used to guide the use of new immune therapies in people living with HIV, cancer and other illnesses.
Through this study, investigators would like to understand the rates of different HLA types in people living with HIV. This will help us plan for future studies of new treatments that only work on people with HLA type.
The Harrison Wing outpatient department and the HIV/Hepatitis Depts of Chelsea & Westinster represent a diverse population with people living with HIV (PLHIV) and Hepatitis, having diverse genetic backgrounds. The HIV cohort is approximately 40% Black African. Within the white population, approximately 40% were not born in the UK and a significant proportion outside Europe. The Hepatitis cohort is equally as diverse. The genetic mix of the white population cannot therefore be assumed to follow expected prevalence for a UK or European population.
Recruiting from this clinic group will facilitate the inclusion of people from diverse backgrounds being identified for future research that is HLA restricted as well as enabling timely recruitment when such studies open.
Participants will be asked to provide a small blood samples (half a teaspoon), which will be tested for HLA typing in the hospital laboratory and consent to having some of their medical history collected.REC name
Wales REC 3
REC reference
23/WA/0114
Date of REC Opinion
28 Mar 2023
REC opinion
Favourable Opinion