HIV Bioresource
Research type
Research Study
Full title
Establishment of HIV BioResource
IRAS ID
126883
Contact name
Fiona Burns
Contact email
Sponsor organisation
University College London
Research summary
The HIV BioResource will build on the existing Cambridge and UCL BioResource, and will form part of the National NIHR BioResource. The NIHR BioResource is a collaboration between five Biomedical Research Centres (UCL, Imperial, Kings/IoP, Oxford and Cambridge) and one Biomedical Research Unit (Leicester) to establish a federated database of healthy individuals and patients with neurological, cardiovascular, or infectious/inflammatory or immune disorders or with rare diseases, who are consented for recall for research on the basis of genotype or phenotype. The aim of the NIHR BioResource is to build on and integrate existing resources to promote recruitment of well genotyped and phenotyped participants into local studies coordinated through existing Clinical Research Facilities within NIHR Biomedical Research Units and Centres.
The HIV BioResource will contribute to this national endeavour through local recruitment of 10,000 patients from HIV cohorts at affiliated hospitals. The HIV BioResource will collect and store blood samples and derivatives including DNA from the 10,000 individuals. The HIV BioResource will take advantage of links with the UK Collaborative HIV Cohort Study (UK CHIC) and the UK HIV Drug Resistance Database (UK HDRD), which together represent two of the largest and most productive HIV cohort studies/databases in the world, to explore host genetic predictors/correlates with a range of clinical and virological phenotypes.
Samples will be collected and processed at the five participating clinical sites, and stored at the UCL-RFH Biobank and the Kings College London Infectious Diseases Biobank. The HIV BioResource will be based on the Cambridge BioResource (REC no: 04/Q108/44. Biobank)REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
13/LO/1029
Date of REC Opinion
6 Sep 2013
REC opinion
Further Information Favourable Opinion