Hidradenitis Suppurativa long term outcomes following surgery
Research type
Research Study
Full title
A feasibility study to locate and recruit patients who underwent surgery for Hidradenitis Suppurativa between 1974-1991 and assess their long term outcomes
IRAS ID
201000
Contact name
Bronywn Hughes
Contact email
Sponsor organisation
Portsmouth Hospitals NHS Trust
Duration of Study in the UK
0 years, 11 months, 25 days
Research summary
Hidradenitis Suppurativa (HS) is a chronic, inflammatory, debilitating skin disease involving the apocrine gland-bearing areas of the body, commonly the inguinal, axillary and anogenital areas. The clinical course is variable ranging from a few recurrent, isolated nodules to deep fluctuant cysts with draining sinuses and fistulae resulting in scar formation. Severe forms of HS can progress to disabling end-stage disease which can have a significant impact on quality of life and often necessitates surgical intervention.\n\nThe prevalence of HS has been reported to be as high as 4% with more females being affected than males (ratio 3:1). Unfortunately, despite the high prevalence there are limited treatment options and few large-scale randomized controlled trials investigating efficacy of treatment.\n\nWe have unique access to the records of approximately 350 patients with HS who were managed surgically over a period of 27 years from 1974 to 1991. This cohort of patients was recruited to a study at the time of surgery which was written up as an MD thesis and subsequently published (Harrison BJ, Mudge M, Hughes LE. Recurrence after surgical treatment of hidradenitis suppurativa. Br Med J (Clin Res Ed) 1987; 294:487). \nThese records include detailed documentation of the affected areas, type of surgical intervention, histological findings, clinical outcome of surgery and need for subsequent surgical intervention. We aim to trace these patients and investigate the long-term outcome of surgery as a treatment option in addition to recording epidemiological aspects of the disease.\n
REC name
South West - Frenchay Research Ethics Committee
REC reference
16/SW/0065
Date of REC Opinion
25 May 2016
REC opinion
Further Information Favourable Opinion