HeVoMRI

• Research type

  Research Study

• Full title

  Development of novel multinuclear magnetic resonance techniques in healthy volunteers (HeVoMRI)

• IRAS ID

  319308

• Contact name

  Stephen Kelleher

• Contact email

  cuh.research@nhs.net

• Sponsor organisation

  Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge

• Duration of Study in the UK

  2 years, 11 months, 31 days

• Research summary

  This is a non-randomised, physiological imaging study split into three imaging techniques across the body including: brain, chest, abdomen/pelvis, breast or extremities MR imaging:
  1) Following injection of 13C-pyruvate, using dynamic 13C MRI and MRSI in up to 40 healthy volunteers/healthy patients
  2) Using Sodium MRI and MRSI in up to 40 healthy volunteers/healthy patients
  3) Following oral consumption of a deuterated glucose drink or deuterated water, using dynamic deuterium metabolic MRI and MRSI imaging (DMI) in up to 40 healthy volunteers/healthy patients
  Healthy volunteers/healthy patients will be allocated to one of these imaging techniques by the Chief Investigator or delegate. This will be based on the availability of kits for the Hyperpolarised MRI study, availability of the deuterated drink for the DMI study and/or availability of the research MRI scanner. If healthy volunteers/healthy patients are willing, they may be recruited to all three arms to enable direct comparison.

• REC name

  Yorkshire & The Humber - Leeds East Research Ethics Committee

• REC reference

  23/YH/0127

• Date of REC Opinion

  27 Jun 2023

• REC opinion

  Further Information Favourable Opinion