HeVoMRI

• Research type

  Research Study

• Full title

  Development of novel multinuclear magnetic resonance techniques in healthy volunteers (HeVoMRI)

• IRAS ID

  319308

• Contact name

  Ferdia Gallagher

• Contact email

  fag1000@cam.ac.uk

• Sponsor organisation

  Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge

• Duration of Study in the UK

  2 years, 10 months, 31 days

• Research summary

  This is a non-randomised, physiological imaging study split into three imaging techniques across the body including: brain, chest, abdomen or breast MR imaging:

  1) Following injection of 13C-pyruvate, using dynamic 13C MRI and MRSI in up to 40 healthy volunteers
  2) Using Sodium MRI and MRSI in up to 40 healthy volunteers
  3) Following oral consumption of a deuterated glucose drink or deuterated water, using dynamic deuterium metabolic MRI and MRSI imaging (DMI) in up to 40 healthy volunteers

  Healthy volunteers will be allocated to one of these imaging techniques by the Chief Investigator or delegate. This will be based on the availability of kits for the Hyperpolarised MRI study, availability of the deuterated drink for the DMI study and/or availability of the research MRI scanner. If volunteers are willing, they may be recruited to all three arms to enable direct comparison.

  Each participant will be offered an optional repeat scan within 14 days of their first scan. This will either be a duplication of their first scan in order to determine whether these imaging techniques are repeatable or will be one of the other imaging techniques to determine whether these imaging techniques can provide complementary data when used in combination. Refusal to take part in this optional imaging will not impact their participation in the rest of the study.
  Participants will not receive more than two injections of 13C-pyuvate and will not receive more than two deuterated glucose or two deuterated water drinks.

• REC name

  Yorkshire & The Humber - Sheffield Research Ethics Committee

• REC reference

  23/YH/0059

• Date of REC Opinion

  6 Mar 2023

• REC opinion

  Unfavourable Opinion