Hepatocyte stability
Research type
Research Study
Full title
Using human hepatocytes for estimating the metabolic stability (CLint) of xenobiological compounds (drugs)
IRAS ID
306273
Contact name
Jane McGuffog
Contact email
Sponsor organisation
BenevolentAI
Duration of Study in the UK
4 years, 11 months, 30 days
Research summary
This study uses human liver cells (hepatocytes) obtained from deceased donors to test new drugs. The method used to study how a drug is metabolised by liver cells in the laboratory is called in vitro intrinsic clearance (CLint). CLint is the clearance in the absence of any restricting factors such as blood flow. The data generated from this assay can be used to predict the metabolic clearance in human patients. This aids decision-making during the early drug discovery process as drugs with a favourable clearance profile will be of interest for further development.
REC name
North East - York Research Ethics Committee
REC reference
22/NE/0114
Date of REC Opinion
23 Jun 2022
REC opinion
Favourable Opinion