HD Grid vs Circular mapping catheters
Research type
Research Study
Full title
Comparative study of Advisor HD Grid versus Circular Mapping Catheters in assessment of pulmonary vein isolation following previous ablation for Atrial Fibrillation
IRAS ID
273987
Contact name
John Silberbauer
Contact email
Sponsor organisation
Brighton and Sussex University Hospitals NHS Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Atrial fibrillation (AF) is the most common clinical cardiac rhythm disturbance affecting 1 in 200 people regardless of age. The underlying mechanism has been much debated, and this in part is likely to affect success rates in the treatment of AF. At present, standard care involves a procedure called an ablation. Small burn marks are made inside the heart in an attempt to correct the irregular heart beat by blocking signals from the pulmonary veins by the burn marks. Unfortunately the success rate for treatment is around 50% for patients with persistent AF.
One of the most common reasons that AF recurs following ablation is the result of electrical reconnection of the veins. Repeat ablations can be performed. These procedures utilise specialised catheters in order to detect the location of electrical reconnection around the pulmonary veins that has led to AF recurrence.
A new and commercially available catheter has been developed (with CE marking) to map the electrical activation in the heart in greater detail than before. Higher definition mapping should assist with identifying areas of pulmonary vein reconnection. Our aim is to compare this to a standard mapping catheter in current use, to determine whether it is better, and could lead to more accurate ablation. It is hoped that this would lead to a higher rate of procedural success with shorter procedure times.
REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
21/EE/0033
Date of REC Opinion
15 Mar 2021
REC opinion
Further Information Favourable Opinion