Haemodynamic effects of dobutamine and nitrite in LV dysfunction
Research type
Research Study
Full title
The Impact of Dobutamine and Nitrite on myocardial supply and demand in Heart Failure
IRAS ID
199826
Contact name
Divaka Perera
Contact email
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
There are many treatments that are used that can help support a weakened heart muscle, particularly when the heart weakens to a degree that it cannot provide enough blood to the rest of the body. These include both drugs and mechanical support devices. More often than not drugs are started when the heart is severely weakened to provide support to the rest of the body, but many of these drugs have unknown effects on the heart. Mechanical support devices have been developed to try and obtain the correct balance in helping supply the body with blood but also protecting the heart, however these devices in large clinical trials have not shown to provide a benefit on survival. There has therefore been a renewed interest in studying the drugs that are used to support the body when the blood pressure is low, to establish their exact effects on the heart. One of these medicines is called Dobutamine, and has been used for many decades to support a weakened heart. Its exact effects on both the workload of the heart and the blood supply to the heart are not fully understood. A newer agent called nitrite has been shown to have potential effects on reducing the workload of the heart and dilating blood vessels. It has the potential to be used as a therapy to treat a severely weakened heart, but its exact effects are not fully understood. The aim of this study is to understand fully how these drugs impact on both the blood supply to the heart muscle, and the workload of the heart, through performing catheter based studies following your coronary angiogram.
REC name
London - Westminster Research Ethics Committee
REC reference
16/LO/0505
Date of REC Opinion
25 Jul 2016
REC opinion
Further Information Favourable Opinion