Haemodynamic Changes After Percutaneous Aortic Valve Intervention
Research type
Research Study
Full title
Acute Haemodynamic Changes After Balloon Aortic Valvuloplasty (BAV) and Transcatheter Aortic Valve Implantation (TAVI).
IRAS ID
123464
Contact name
Rafal Dworakowski
Contact email
Sponsor organisation
King's College Hospital
Research summary
Transcatheter aortic valve implantation (TAVI) is a novel key hole procedure for the treatment of severe aortic valve narrowing (stenosis). We have previously shown that after successful TAVI procedure, there is right and left ventricular (LV) impairment noted within 24 hrs of the procedure, which recovers very quickly. These transient disturbances in ventricular performance after TAVI are likely to have an impact on early postoperative recovery and may inform appropriate medical management in the immediate post-procedural period.
We aimed to define the various pressure related changes after balloon aortic vavuloplasty (balloon stretching of the narrowed valve as a temporary procedure before TAVI, which is done in some patients) and TAVI and to understand the mechanism of the observed ventricular impairment and their outcome. This will be done with the help of special catheters used during the procedures and also by ultrasound scan of the heart and specific blood tests. The ultrasound and blood tests will be done immediately after the procedure and also during follow up. The patients will also be assessed for their functional capacity before and one month after the procedure by a walk test, as a marker of functional outcome.
The patients who are involved in our study will be divided into 3 groups: those with good LV function and no coronary artery disease (CAD), those with good LV systolic function and significant CAD, those with significant LV impairment.
The study will be undertaken at King’s College Hospital in London and the patients will be recruited (after fulfilling the inclusion criteria and informed consent) from the outpatient clinic and the wards.All these patients will be followed up regularly in our clinic (which is a standard practice) and assessed for their functional status and outcome.REC name
London - Dulwich Research Ethics Committee
REC reference
13/LO/1542
Date of REC Opinion
20 Jan 2014
REC opinion
Further Information Favourable Opinion