Gut and liver hormones
Research type
Research Study
Full title
Postprandial glycaemia, gut and liver hormone responses in lean and obese controls compared to obese type 2 diabetic subjects: pilot study
IRAS ID
151628
Contact name
Andrew Collier
Contact email
Sponsor organisation
Glasgow Caledonian University
Research summary
The gut produces a number of hormones which control appetite and regulate the bodies ability to store energy taken in during feeding. These hormones from the gut travel in the blood to various organs in the body including the liver and pancreas. In the liver a hormone called IGFBP-1 is produced. IGFBP-1 levels in the blood are modified following a meal and are thought to reflect insulin resistance in the liver.The mechanisms controlling blood IGFBP-1 are not fully understood. Blood IGFBP-1 is increased in type 2 diabetes due to insulin resistance. It is possible that hormones from the gut might directly or indirectly alter the ability of the liver to produce and release IGFBP-1 into the blood. This study will look at whether there is a link between the changes in gut hormones and IGFBP-1 following a meal, and assess these responses in healthy lean and obese individuals and compare these to the responses in subject with obesity and type 2 diabetes.
REC name
North West - Preston Research Ethics Committee
REC reference
14/NW/1060
Date of REC Opinion
3 Jul 2014
REC opinion
Favourable Opinion