GRIPPR study: Post-rehabilitation Spirometry to predict Hyperinflation
Research type
Research Study
Full title
GRIPPR study: Glasgow Hub Lung Volume Reduction (LVR) Service: Identification of hyperinflation post-pulmonary rehabilitation via spirometry
IRAS ID
320220
Contact name
Hannah Bayes
Contact email
Sponsor organisation
NHS Greater Glasgow & Clyde
Clinicaltrials.gov Identifier
23/WS/0034, REC
Duration of Study in the UK
0 years, 6 months, 2 days
Research summary
Emphysema is a chronic lung disease which causes shortness of breath, cough and fatigue. Treatment involves a multidisciplinary approach, which includes education, exercise (pulmonary rehabilitation; PR), smoking cessation, oral and inhaled medications, oxygen therapy, and lung transplantation. Lung volume reduction (LVR) can also be offered to some patients to improve symptoms if they have enlarged (hyperinflation) on breathing tests. LVR can either be via small valves placed into some airways in the lungs or minimally invasive surgery. The best time to consider LVR is at the end of rehanilitaion. However detailed breathing tests are needed to identify hyperinflation, which limits the patent pathway. Values from a simpler breathing test (spirometry) can be used to predict hyperinflation.
We intend to assess the novel service innovation of using handheld spirometry at the end of pulmonary rehabilitation to identify patients with predicted hyperinflation. The spirometry tests will form part of the normal clinical assessment at the end of PR. The study aims to determine the proportion of patients with potential hyperinflation on spirometry following pulmonary rehabilitation that are then potentially eligible for lung volume reduction. Two spirometry prediction equations will also be compared.
It is intended that validation of this approach to identifying patients with hyperinflation will have widespread utility and benefit in the patient pathway. Particularly as the approach will provide a single point of access to the LVR assessment pathway, not reliant on either primary or secondary care referral, but rather only on engagement of the patient in pulmonary rehabilitation.
REC name
West of Scotland REC 1
REC reference
23/WS/0034
Date of REC Opinion
21 Mar 2023
REC opinion
Further Information Favourable Opinion