GPD Study
Research type
Research Study
Full title
Genotype, Phenotype and Dietary Correlation in Retinal Degeneration
IRAS ID
321043
Contact name
Samantha De Silva
Contact email
Sponsor organisation
Oxford University Hospitals NHS Foundation Trust
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Retinal degeneration has a very significant impact on quality of life. For example, age-related macular degeneration (AMD) is one of the leading causes of vision impairment worldwide. AMD involves progressive damage to the central part of the retina (the tissue at the back of the eye that detects light) called the macula, which is responsible for our central vision and functions such as reading and seeing faces or fine detail. Treatment is currently available for one type of AMD called “wet” AMD in which abnormal blood vessels grow under the retina. However, there is no established treatment for patients with “dry” AMD who are affected by progressive loss of vision. The causes of retinal degeneration remain incompletely understood but appear to be related to a combination of genetic, dietary, and environmental factors such as smoking, which all affect the risk of an individual developing and then progressing to advanced stages of the disease. The aim of this study is to characterise the correlation between genetic factors, clinical features and lifestyle factors in patients with retinal degeneration.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
23/EE/0207
Date of REC Opinion
18 Sep 2023
REC opinion
Further Information Favourable Opinion