GO-SAH Version 1
Research type
Research Study
Full title
Genetics of outcome after aneurysmal subarachnoid haemorrhage
IRAS ID
320119
Contact name
Diederik Bulters
Contact email
Sponsor organisation
University Hospital Southampton NHS Foundation Trust
Duration of Study in the UK
4 years, 11 months, 28 days
Research summary
A brain aneurysm is a bulge in the wall of a blood vessel in the head. They generally cause no symptoms but can burst leading to a bleed on the surface of the brain, this is a type of stroke, called a subarachnoid haemorrhage. It is the most severe type of stroke and usually results in death or disability.
Very little is known about what mechanisms cause brain damage and disability after a subarachnoid haemorrhage. This lack of understanding unfortunately means that we have very few treatments to improve the outcome after these bleeds. In fact, there is only one medication routinely used after this type of stroke and this may only improve outcome by a small amount.
There is evidence that differences in individuals genetic background can influence outcome after subarachnoid haemorrhage. The aim of this study is to identify which genes influence outcome. Identifying these genes will help us to understand what mechanisms lead to brain damage and poor outcomes after subarachnoid haemorrhage. With this information we hope to ultimately develop treatments to reduce disability and improve outcome after subarachnoid haemorrhage.
REC name
Wales REC 4
REC reference
24/WA/0043
Date of REC Opinion
10 Apr 2024
REC opinion
Further Information Favourable Opinion