GO for IT
Research type
Research Study
Full title
The effect of a single bout of high-intensity interval training on glucose responses in white European and south Asian patients at risk of type 2 diabetes.
IRAS ID
167328
Contact name
Wendy Gamble
Contact email
Sponsor organisation
University Hospitals of Leicester NHS Trust
ISRCTN Number
ISRCTN12337078
Duration of Study in the UK
0 years, 8 months, 26 days
Research summary
Primary research question – what is the effect of a single bout of high-intensity interval training compared to matched-work continuous exercise on post-meal glucose responses in white European and south Asian patients at risk of type 2 diabetes?
Secondary research question – what is the effect of HIT on cardiovascular risk biomarkers and psychological measures of enjoyment?
Why? Many people say that they do not have time to perform the recommended amount of physical activity. High-intensity interval training (HIT) has been proposed as a time-saving form of exercise. HIT improves fitness but the benefits to metabolic health e.g. blood glucose regulation are unclear. It is also uncertain whether people from different ethnic backgrounds respond in the same way to the same physical activity. This is important to establish If HIT is to be recommended to the general population as a therapeutic health tool for people at risk of or with diabetes.
What? A form of HIT that involves exercising on a treadmill for 10x60-seconds with 60-seconds rest will be trialled. Blood samples will be taken so that levels of blood glucose and insulin can be tested.
Who? South Asian and white European adults whose blood glucose is higher than normal but not high enough to be diagnosed with type 2 diabetes will be recruited. Individuals who are between the ages of 50-75 will be included.
Where? Leicester Diabetes Centre, Leicester General Hospital.
How? Eligible participants will visit the centre four times, each visit separated by 1-week. The first visit will be a familiarisation visit lasting 2-hours. On each of the treatment days the participant will remain in the laboratory for 8-hours. In the control condition participants will remain seated for the whole day. The other two days will run exactly the same except that HIT or moderate-intensity continuous exercise will be performed for approximately 30-minutes.
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
15/EM/0259
Date of REC Opinion
31 Jul 2015
REC opinion
Further Information Favourable Opinion