GM Cardio-IMID

• Research type

  Research Study

• Full title

  Greater Manchester CARDIOvascular Pathology in Immune-Mediated Inflammatory Diseases

• IRAS ID

  320989

• Contact name

  Maya H Buch

• Contact email

  maya.buch@manchester.ac.uk

• Sponsor organisation

  The University of Manchester

• Clinicaltrials.gov Identifier

  N/A, N/A

• Duration of Study in the UK

  9 years, 3 months, 1 days

• Research summary

  The researchers would like to know more about cardiovascular abnormalities in patients with immune-mediated inflammatory diseases (IMID) and with the aim to provide new biomarkers (clinical, blood, imaging) for early diagnosis, prognosis and prediction of CVD in patients with IMID. This is important as there are still many things that are not known about this and finding out more could improve how patients are treated in future.

  Participants with IMID diagnoses will be recruited from rheumatology/cardiology departments as in-patients or out-patients. Once consented, researchers will collect past, present and future clinical information about them, including routine cardiovascular imaging and blood tests. Participants will also be asked to complete questionnaires at pre-determined intervals. The participants could also be approached to take part in the following sub-studies; Biological sub-study, in which blood and urine would be collected; And the Imaging-sub study, in which one or more of Echocardiography, Cardiovascular Magnetic Resonance Imaging (CMR) and Laser Doppler Imaging (LDI) will be performed. We will also recruit participants with CVD without IMID and healthy volunteers as comparison groups.
  
  The research is to be funded by the NIHR Manchester BRC (‘Integrated Cardiovascular’ and ‘Rheumatic & Musculoskeletal Diseases’ themes). Other funding eg Manchester Academic Health Sciences and a recently awarded Medical Research Council Partnership grant will also support this programme. The study will recruit in specialist NHS centres; Recruitment will start in Manchester University Hospitals NHS Foundation Trust.

• REC name

  East of England - Cambridge Central Research Ethics Committee

• REC reference

  23/EE/0234

• Date of REC Opinion

  22 Feb 2024

• REC opinion

  Further Information Favourable Opinion