Glycemic and insulin metabolism testing of arabinoxylan enriched bread
Research type
Research Study
Full title
Glycemic and insulin metabolism testing of arabinoxylan enriched bread
IRAS ID
340491
Contact name
Gary Frost
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
The significance of dietary fibre in promoting human health has garnered attention, given its association with reducing the risk of cardiovascular disease, type 2 diabetes, and various cancers.
Despite established guidelines recommending a daily fibre intake of 30g, UK adults typically consume only 18g per day. Cereals, particularly bread, contribute significantly to daily fibre intake, with much of it derived from low-fibre white bread. Consequently, there's a demand for consumer-accepted, high-fibre bread options.
Wheat flour's major fibre components are arabinoxylan (AX) and β-glucan. Genetic variations in AX content have facilitated the production of high-AX bread at Rothamsted Research. This study aims to evaluate the impact of bread samples, each varying in fibre content, on blood glucose and insulin metabolism. We will also assess the impact of AX-enriched bread in people with different phenotypes of glucose intolerance. Glucose intolerance can be divided into impaired fasting glucose (IFG), impaired glucose tolerance (IGT), increased HbA1c (IA1c), and their association with metabolic profile and atherogenic lipid profile. We will explore the impact of these bread samples on these phenotypes and the drivers of abnormal glucose tolerance, including insulin and c-peptide.REC name
London - Fulham Research Ethics Committee
REC reference
24/LO/0671
Date of REC Opinion
14 Oct 2024
REC opinion
Further Information Favourable Opinion