Glycaemic response to high REsistant STarch bread - REST study

• Research type

  Research Study

• Full title

  Glycaemic response to high REsistant STarch bread (REST study) A randomised double-blinded controlled trial

• IRAS ID

  262271

• Contact name

  Marina Corrado

• Contact email

  marina.corrado@quadram.ac.uk

• Sponsor organisation

  Quadram Institute Bioscience

• Duration of Study in the UK

  1 years, 1 months, 1 days

• Research summary

  The primary aim of this study is to determine whether, in healthy subjects, consumption of white bread made from sbeIIa/b wheat flour with a high resistant starch (RS) content at breakfast, gives rise to lower capillary blood glucose levels compared with consumption of a wild-type (WT) control white bread.
  As part of this study, we will also determine whether, in healthy subjects, consumption of sbeIIa/b white bread gives rise to a lower glucose concentration in interstitial fluid as measured by a Continuous Glucose Monitoring device (CGM) compared with consumption of a WT control white bread. We will also explore satiety and energy intake changes following consumption of the sbeIIa/b white bread compared with consumption of the WT control white bread.
  We hypothesise that consumption of sbeIIa/b white bread with high RS content has potential to modulate glucose response and increase satiety compared with conventional white bread. High RS foods could be used to complement fibre intake from wholegrain foods. However, further research studies are needed to quantify the effect of this dietary intervention. A randomised, double-blind, two-phase crossover study will be used to address these questions. Twenty-five healthy participants, male and female, aged between 18 and 65 years, will be recruited onto this study. Eligible participants will be fitted with a CGM device and will attend the Quadram Institute Clinical Research Facility (QI CRF) in Norwich for two half-day dietary interventions at least 4 days apart and within 14 days of fitting the CGM device.

• REC name

  East of England - Cambridge South Research Ethics Committee

• REC reference

  19/EE/0260

• Date of REC Opinion

  4 Nov 2019

• REC opinion

  Further Information Favourable Opinion