Glasgow Traumatic Brain Injury Archive
Research type
Research Tissue Bank
IRAS ID
225271
Contact name
William (Willie) Stewart
Contact email
Research summary
NHS Greater Glasgow and Clyde Bio-repository: Glasgow Traumatic Brain Injury Archive. A satellite collection under the governance of the NHS Greater Glasgow & Clyde Bio-repository
REC name
West of Scotland REC 1
REC reference
17/WS/0164
Date of REC Opinion
7 Nov 2017
REC opinion
Further Information Favourable Opinion
Data collection arrangements
NHS Greater Glasgow and Clyde (GGC) Bio-repository will house a register of prospective tissue donors who wish to gift their tissue for medical research in the event of their death. In keeping with local/national autopsy authorisation procedures, the next of kin will give their formal authorisation (consent) for a post mortem examination to be carried out and for tissue to be collected for future medical research purposes at the time of death. All tissue collected will be stored under the auspices of the GGC Bio-repository who will also be responsible for the governance and access to the banked samples
Research programme
The proposed resource is intended to address the pressing need for suitable human tissue to support national and international research studies directed towards understanding the neuropathological consequences of survival from traumatic brain injury (TBI). Currently, only one comprehensive research archive of human tissues to support studies in TBI exists internationally, the Glasgow TBI Archive. However, this long established and internationally regarded archive comprises pre-2006 tissue holdings only, with the overwhelming majority of samples from patients dying in the acute phase post TBI. In the past decade there has been increasing appreciation that for many patients TBI initiates a life-long chronic illness. Our and others' recent studies in this field have shown complex and evolving pathologies in survivors of TBI which might contribute to the recognised increased risk of dementia in this population; an issue attracting considerable attention in the media at present through the proposed link between sports brain injury and dementia. This application seeks to address the growing demands from patients and patient groups for participation in research through post-mortem tissue donation. In turn, the donated materials will contribute to the existing, highly regarded Glasgow TBI Archive to continue to support global research in this field.
RTBTitle
NHS Greater Glasgow and Clyde Bio-repository: Glasgow Traumatic Brain Injury Archive. A satellite collection under the governance of the NHS Greater Glasgow & Clyde Bio-repository
Establishment organisation
NHS Greater Glasgow and Clyde Bio-repository
Establishment organisation address
Pathology Department,L3/B/012
Laboratory Medicine Building
Queen Elizabeth University Hospital, Glasgow
G51 4TF