Glanzmann Thrombasthenia NHS

• Research type

  Research Study

• Full title

  Glanzmann Thrombasthenia Natural History Study

• IRAS ID

  345582

• Contact name

  Suthesh/S. Sivapalaratnam

• Contact email

  s.sivapalaratnam@nhs.net

• Sponsor organisation

  UMC Utrecht

• Duration of Study in the UK

  10 years, 0 months, 1 days

• Research summary

  Glanzmann Thrombasthenia is a rare autosomal recessive platelet disorder characterized by a lack of functional integrins alpha IIb or beta III (glycoproteins IIb/IIIa). The clinical phenotype is dominated by an increased mucocutaneous bleeding tendency. . In absence of a primary bleeding prophylaxis, the current treatment of Glanzmann thrombasthenia is mainly focused on prevention or management of bleeding.

  The purpose of the Glanzmann thrombasthenia Natural History study is to describe the natural history of Glanzmann thrombasthenia and the range and incidence of bleeding symptoms, treatments and complications related to Glanzmann thrombasthenia, and the quality of life of these patients.

• REC name

  South Central - Oxford C Research Ethics Committee

• REC reference

  24/SC/0413

• Date of REC Opinion

  15 Jan 2025

• REC opinion

  Further Information Favourable Opinion