GI symptoms in connective tissue disease & collagen vascular disorders
Research type
Research Study
Full title
Study of the incidence,prevalence and overall burden of gastrointestinal tract symptoms and disease in various types of connective tissue diseases and collagen vascular disorders
IRAS ID
194008
Contact name
Nashiz Inayet
Contact email
Sponsor organisation
St George's, University of London and St George's University Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Connective tissue is a biological tissue of mesodermic origin with extensive extracellular matrix that supports, binds together ,separates and protects organs. It is composed of ground substance,cells and two major structural proteins – collagen and elastin. These structural proteins can be affected by inflammatory, heritable and environmental factors leading to destruction in strength or elasticity. \nIn the gastrointestinal tract, connective tissue makes up two of the four layers of the digestive tract wall yet very little is known about the exact role it plays in causing various symptoms and disorders affecting this part of the body including functional gastrointestinal disorders. We are therefore interested in evaluating the overall impact of gastrointestinal symptoms on the general health and well being of patients diagnosed with various types of connective tissue disorders. \nWe aim to do this with the use of short validated questionnaires filled out by attendees of the out-patient clinics at St George’s Hospital. These will then be compared with similar data collected through same questionnaires filled out by age and sex matched controls, who will be patients attending the fracture clinic at St George’s Hospital.\n
REC name
South West - Central Bristol Research Ethics Committee
REC reference
16/SW/0304
Date of REC Opinion
30 Nov 2016
REC opinion
Further Information Favourable Opinion