Geospatial mapping of nontuberculous mycobacteria in cystic fibrosis
Research type
Research Study
Full title
Spatial study of nontuberculous mycobacteria in cystic fibrosis patients in the UK.
IRAS ID
251985
Contact name
Dorothy Grogono
Contact email
Sponsor organisation
Royal Papworth Hospital NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
The aim of this study is to explore geographical differences in nontuberculous mycobacteria infection in patients with cystic fibrosis. One of the main questions we we hope to answer is whether or not patients with similar strains attend the same hospital or live close to one another. We hope to do this by comparing whole genome sequencing data of M. abscessus (already collected - IRAS project ID: 97508) with geographical data from the CF registry (already collected).
Nontuberculous mycobacteria can cause lung damage in patients with cystic fibrosis. Mycobacterium abscessus in particular is a multi-drug resistant organism which causes an accelerated decline in lung function. Evidence has recently emerged that this organism can be transmitted between patients and that there are dominant circulating clones within the cystic fibrosis population, which appear to lead to worse infection. At present very little is understood about the geographical variation of these species.
REC name
East of England - Cambridgeshire and Hertfordshire Research Ethics Committee
REC reference
18/EE/0406
Date of REC Opinion
28 Mar 2019
REC opinion
Further Information Favourable Opinion