Genetic Predisposition to Cancer and Other Tumours
Research type
Research Study
Full title
Genetic Predisposition to Cancer and Other Tumours
IRAS ID
279934
Contact name
Gareth Evans
Contact email
Sponsor organisation
University of Manchester
Duration of Study in the UK
6 years, 5 months, 31 days
Research summary
In this research study, we are hoping to discover changes in our genetic material (DNA) that may cause people to develop cancer or tumours. We are already aware of some genetic changes that some of the population have, which mean they are at an increased risk of developing cancer or tumours. However, there are still many patients who have had cancer and/or a strong family history of cancer without a known genetic change. We suspect that there are more genetic changes that are yet to be identified. We are hoping that by looking at different regions of the genetic material, than is currently investigated in routine clinical testing, we may be able to identify further genetic changes that increase the risk of developing cancer or tumours.
Participants will be invited to the research study due to them previously having been through clinical testing to try and identify the genetic cause for their personal/ family history of cancer. Participants will be recruited at a number of NHS trusts across the UK with The Manchester Centre for Genomic Medicine being the coordinating centre. The study will involve participants providing a blood sample or access to a sample previously taken to allow genetic analysis by the study team. The study is being funded through 2 research grants, from Prevent Breast Cancer who are a non-commercial partner of The National Institute of Health Research and also the Department of Defense office of the Congressionally Directed Medical Research Programs (CDMRP).
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
20/YH/0294
Date of REC Opinion
16 Nov 2020
REC opinion
Favourable Opinion