Genetic factors involved in eyelid mBCC and SGC
Research type
Research Study
Full title
Identification of genetic factors involved in morphoeic basal cell (mBCC) and sebaceous gland carcinoma (SGC) of human eyelid tumours with a view to identifying potential treatment targets.
IRAS ID
119204
Contact name
John Bladen
Contact email
Sponsor organisation
Queen Mary, University of London
Clinicaltrials.gov Identifier
RJ113/N155 for TCC, GSTFT R&D Trust R&D registration number ; 008621GM, Barts Health NonCTIMP Conditions of sponsorship ReDA number: ; 10/H0106/57-2012ETR28, MEH Biobank Ethical approval for current study
Research summary
Aims
1) Skin cells (surface keratinocytes and below the surface fibroblasts) are thought to play a major role in priming the local environment to orchestrate tumour spread. We aim to identify why mBCC and SGC can spread so easily and aggressively within the layers of the skin by examining the patterns of cell migration and invasion through developing 3D ‘human-like’ (organotypic) derived from fresh human samples.
2) To understand the molecular cell biology of human eyelid SGC and mBCC looking into key genetic signaling pathways in cell lines and the 3D organotypic models.
3) Epidermal growth factor (EGF) signalling is involved in normal cell division and its role in the different types of tumours will be investigated to see if there is any disruption in aggressive versus benign eyelid cancers.
4) Identify disease genes involved in SGC and mBCC using next-generation sequencing and array analysis. This may lead to the identification of potential treatment targets for further application.REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
14/NW/1080
Date of REC Opinion
18 Jul 2014
REC opinion
Further Information Favourable Opinion