Genetic and humoral factors predicting recurrence of IgA Nephropathy
Research type
Research Study
Full title
Identifying the biomarkers (genetic and humoral factors) that predict recurrence of IgA Nephropathy in renal transplant patients
IRAS ID
125120
Contact name
Paul Brenchley
Contact email
Sponsor organisation
Central Manchester University Hospital Foundation Trust
Research summary
IgA Nephropathy (IgAN) is a major cause of kidney damage occurring as an isolated renal disease or in conjunction with a systemic illness, as in Henoch-Schonlein Purpura (HSP). It can usually be controlled with tight blood pressure management but some patients will progress and will eventually require dialysis or kidney transplantation.
After kidney transplantation, the disease can recur and cause graft failure despite good blood pressure control and immunosuppressive medicines. We believe these patients have a more ‘virulent’ form of IgAN with factors causing kidney damage: we intend to identify such factors so we may predict which patients may be at an increased risk of recurrence of IgAN.
Genetic factors play a part in the development of the disease, although the exact mechanisms are unknown.
We will study the clinical phenotype and genetics of patients with disease recurrence after transplantation, anticipating that genetic testing may provide a means of predicting which groups of patients are more likely to suffer from IgAN post transplant, with the implication that patients with similar characteristics (phenotype) may be at risk from their original disease. We also intend to study serum biomarkers including factors that control the interaction of IgA complexes with tissue components in order to further understand the disease process.REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
13/EE/0316
Date of REC Opinion
4 Sep 2013
REC opinion
Favourable Opinion