Generation of human cell lines from tumour tissue
Research type
Research Study
Full title
Generation of human cell lines from tumour tissue
IRAS ID
167581
Contact name
Tony Dhillon
Contact email
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
We are looking at new ways of treating cancers and trying to identify new molecules that could be used in designing new treatments. In order for us to do this we have to have cancer cells from patients to work on in the laboratory. The majority of cancer cell lines which are used in the lab have been derived from a human tumour but in order for them to grow continuously and not die, they have to be ‘transformed’ by adding in a gene which causes them to divide continuously, so called ‘immortalisation’. However, there is concern that during this process the tumour cell is altered in such a way that it no longer bears a genetic resemblance to the cancer it originated from. We aim to take tumour tissue from patients at a time routine surgery is being performed (and this tissue is spare and not needed for diagnosis), extract cancer cells from the tissue and grow these cells in our laboratory.
REC name
West Midlands - Edgbaston Research Ethics Committee
REC reference
15/WM/0070
Date of REC Opinion
25 Feb 2015
REC opinion
Further Information Favourable Opinion