Gene expression studies in severe asthma
Research type
Research Study
Full title
Gene expression studies in severe steroid-sensitive and steroid-resistant asthma
IRAS ID
158661
Contact name
Resa Razavi
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
2 years, 11 months, 31 days
Research summary
We have previously conducted a clinical study investigating the effect of vitamin D supplementation on severe asthma, and in particular patients whose asthma does not respond to steroids. As part of the study participants agreed to donate blood samples for immunological studies including gene expression studies. It was not possible to do the gene expression studies whilst the study was ongoing - this new ethical approval will allow us to conduct the planned gene expression studies. We hope that by identifying genes differentially expressed in severe asthma, in particular those associated with steroid resistance and vitamin D response, we will be able advance our understanding of severe asthma, and in future develop new therapies.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
15/EM/0088
Date of REC Opinion
4 Mar 2015
REC opinion
Further Information Favourable Opinion