Gastrointestinal diseases questionnaire
Research type
Research Study
Full title
Questionnaire study investigating the socio-environmental and familial contributors to gastrointestinal diseases.
IRAS ID
129502
Contact name
Jack Satsangi
Contact email
Sponsor organisation
University of Edinburgh Research Governance & QA Office
Research summary
We propose a gastrointestinal questionnaire to be administered to patients attending for routine hospital appointments. The aim of the questionnaire is to document robust details about patient social, environmental and familial (family history) factors which may contribute to gastrointestinal disease.\n\nThe proposed questionnaire will allow patient details to be recorded contemporaneously. Retrospective review of patient notes is unlikely to provide all details required for research purposes as details (e.g. family history, diet and smoking history) are not always recorded in clinical notes. \n\nThe questionnaire study will be used to:\ni) The phenotypic details from newly diagnosed patients will allow an observational, cross-sectional study of a local cohort with gastrointestinal diseases. Descriptive statistics will correlate disease indices from validated disease activity scores with the various lifestyle/risk factors for developing disease\n\nii) To be used in conjunction with biobanked samples (collected as part of a separate BioResource study), providing baseline demographic and phenotypic details, to allow increased utility of the biological samples (i.e. patients stratification i.e. according to gastrointestinal disease, diet type, smoking status, disease activity index score), which will be used from multi-omics projects (collected as part of separate Bioresource study).The provision of high quality, rigorous scientific output (required for publication in the most highly regarded journals) from the biological samples, relies on high quality, uniform phenotypic data from study participants. Various biological processes (I.e. DNA methylation status) may vary according lifestyle factors (e.g. smoking, diet, medication history) and therefore detailed information on these factors are required for valid scientific output from the biobanked samples.
REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
13/WM/0255
Date of REC Opinion
18 Jun 2013
REC opinion
Favourable Opinion