GARMIn: The Role of GABAB Receptor Mechanisms in Cough.
Research type
Research Study
Full title
The Role of GABA-B Receptor Mechanisms in Cough: Effect of Lesogaberan, Baclofen and Placebo on Experimentally Induced Cough Responses in Healthy Controls.
IRAS ID
132737
Contact name
Jaclyn Smith
Contact email
Sponsor organisation
University Hospital of South Manchester NHS Foundation Trust
Research summary
Cough is a protective reflex which is used to clear the upper airways of irritating material or mucus (phlegm) and yet it is the most common complaint for which people seek medical advice. Most coughs are caused by an infection, such as a cold, which usually settles within 8 weeks. However, some people develop persistent coughing which can last from 8 weeks to several years. This persistent cough is known as ‘chronic cough’. Chronic cough is a common and troublesome problem and is associated with poor quality of life. Effective, well-tolerated treatments for cough remain a significant unmet need which may be due to the poor understanding of the mechanisms which underlie cough in humans. This research has therefore been designed to improve our understanding of the mechanisms that control the human cough reflex by investigating whether two drugs which act of different parts of the nervous system reduce coughing in a similar way.
In this study we aim to recruit 15 healthy volunteers to attend the University Hospital of South Manchester NHS Foundation Trust on five separate occasions. During study visits participants will be given either lesogaberan, baclofen or placebo in a randomised order, perform a capsaicin cough challenge test and undergo safety monitoring including blood tests, liver and kidney function tests, and electrocardiograms.
REC name
North West - Haydock Research Ethics Committee
REC reference
13/NW/0715
Date of REC Opinion
24 Sep 2013
REC opinion
Favourable Opinion