GAPS: Gastrostomy in Atypical Parkinsonian Syndromes
Research type
Research Study
Full title
GAPS: Gastrostomy in Atypical Parkinsonian Syndromes
IRAS ID
344291
Contact name
Boyd Ghosh
Contact email
Sponsor organisation
University Hospital Southampton NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Background:
Progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA) are rare neurodegenerative diseases. Swallowing difficulties often form part of the disease particularly in mid to late stages. There is often debate as to the benefit of feeding tubes such as a percutaneous endospcopic gastrostomy (PEG) and a radiologically inserted gastrostomy (RIG) to feed patients in later stages of the illnesses. Literature suggests that inserting a feeding tube in people with dementia does not lead to better outcomes but it is unclear if there is a benefit in PSP, CBD and MSA.
Methods:
We aim to determine whether feeding tubes are helpful in those with PSP, CBD and MSA. We will carry out a retrospective case notes analysis on patients seen in our service over the last 8 years. We currently have around 70 patients with PSP, CBD and MSA noted to have had feeding tube discussions of which about half elected not to have a feeding tube. The researcher will carry out a retrospective analysis on our case notes to determine longevity, functional status, speed of deterioration and amount of health care use for patients with and without a feeding tube placement.
Implications:
Many gastroenterologists and dieticians are reluctant to place feeding tubes in patients with PSP and CBD. A clear result suggesting benefit or not would provide much needed guidance to Neurologists and allied health practitioners alike. If feeding tubes are found to be beneficial then this will allow more patients and their families to benefit from this intervention.REC name
South Central - Hampshire A Research Ethics Committee
REC reference
24/SC/0198
Date of REC Opinion
21 Jun 2024
REC opinion
Favourable Opinion